Translocation-related sarcomas.
Författare
Summary, in English
Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses.
Publiceringsår
2009
Språk
Engelska
Sidor
312-323
Publikation/Tidskrift/Serie
Seminars in Oncology
Volym
36
Issue
4
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
W.B. Saunders
Ämne
- Cancer and Oncology
- Medical Genetics
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0093-7754