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Passerine MHC: genetic variation and disease resistance in the wild

In English

Författare

Summary, in English

The passerine major histocompatibility complex (MHC) class I and IIB genes are different from those of the avian model species the chicken because passerines have (1) a larger number of MHC genes, (2) MHC genes with longer introns, and (3) MHC genes that are pseudo-genes. Most passerine MHC genes are transcribed (coding), extremely variable and subject to balancing selection. The high genetic diversity of the MHC genes of passerines is most likely maintained by selection from a large number of different pathogens. Association between MHC alleles and resistance to avian malaria infections have been reported in House Sparrows and Great Reed Warblers. Passerines are infected by a large number of different avian malaria infections. Therefore passerines and avian malaria is a study system that is well-suited to investigations of balancing selection and associations between MHC genes and disease resistance.

Publiceringsår

2007

Språk

Engelska

Sidor

469-477

Publikation/Tidskrift/Serie

Journal of Ornithology

Volym

148

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Biological Sciences

Nyckelord

  • MHC class I and class II
  • passerines
  • Avian
  • balancing selection
  • disease resistance
  • malaria

Status

Published

Projekt

  • Avian MHC genes

Forskningsgrupp

  • Molecular Ecology and Evolution Lab

ISBN/ISSN/Övrigt

  • ISSN: 2193-7206