Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Aspects of tumour demarcation in rats by means of laser-induced fluorescence and haematoporphyrin derivatives

In English

Författare

Summary, in English

The effects of different parameters of interest for the localization of malignant tumours in situ by means of laser-induced fluorescence and haematoporphyrin derivatives were investigated. Such parameters are drug composition, drug concentration, laser pulse energy and excitation wavelength. In order to assess the relative merits of the two tumour-seeking agents Photofrin (haematoporphyrin derivative) and Photofrin II (dihaematoporphyrin ether) we have performed a comparative study on rat tissues. The results suggest that Photofrin is at least as good as the therapeutically more potent agent Photofrin II. A linear relation between drug dose and recorded porphyrin fluorescence intensity was also found. Using not only the porphyrin fluorescence, but also natural tissue autofluorescence, better tumour demarcation is observed when utilizing an excitation wavelength shorter than the porphyrin excitation peak at 405 nm.

Publiceringsår

1988

Språk

Engelska

Sidor

239-248

Publikation/Tidskrift/Serie

Lasers in Medical Science

Volym

3

Issue

239

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Atom and Molecular Physics and Optics

Nyckelord

  • Autofluorescence
  • Cancer detection
  • Dihaematoporphyrin ether
  • Fluorescence
  • Haematoporphyrin derivative

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0268-8921