B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.
Författare
Summary, in English
To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.
Publiceringsår
2008
Språk
Engelska
Sidor
138-145
Publikation/Tidskrift/Serie
Cancer Letters
Volym
259
Issue
2
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cancer and Oncology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1872-7980