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New directions of miniaturization within the biomarker research area

Publiceringsår: 2004
Språk: Engelska
Sidor: 3479-3491
Publikation/Tidskrift/Serie: Electrophoresis
Volym: 25
Nummer: 21-22
Dokumenttyp: Artikel i tidskrift
Förlag: John Wiley & Sons


An overview of the current trends within protein expression profiling is given where multidimensional separation of both gel and liquid phase techniques linked to mass spectrometry is viewed as a major route in the global proteome mapping. A clear trend in these biochemical developments is the effort to sequence and identify low-abundant protein expressions where assay miniaturization and integrated sample processing play a central role. Two areas of miniaturization within the proteomics field are addressed: (i) sample cleanup and enrichment, and (ii) silicon microstructure developments for protein chip microarrays.


  • Medical Engineering
  • Analytical Chemistry
  • Review
  • Biomarker
  • Miniaturization


  • ISSN: 0173-0835

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