New directions of miniaturization within the biomarker research area
Författare
Summary, in English
An overview of the current trends within protein expression profiling is given where multidimensional separation of both gel and liquid phase techniques linked to mass spectrometry is viewed as a major route in the global proteome mapping. A clear trend in these biochemical developments is the effort to sequence and identify low-abundant protein expressions where assay miniaturization and integrated sample processing play a central role. Two areas of miniaturization within the proteomics field are addressed: (i) sample cleanup and enrichment, and (ii) silicon microstructure developments for protein chip microarrays.
Publiceringsår
2004
Språk
Engelska
Sidor
3479-3491
Publikation/Tidskrift/Serie
Electrophoresis
Volym
25
Issue
21-22
Dokumenttyp
Artikel i tidskrift
Förlag
John Wiley & Sons Inc.
Ämne
- Medical Engineering
- Analytical Chemistry
Nyckelord
- Review
- Biomarker
- Miniaturization
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0173-0835