The role of p-c-Jun in survival and outgrowth of developing sensory neurons
Författare
Summary, in English
c-jun activation has been implicated not only in neuronal apoptosis, but also in survival and regeneration. This Janus facet of c-Jun activation could be related to neuronal cell type or to the developmental stage of the neuron. We investigated c-Jun activation in E18 sensory neurons. Cultures of rat dorsal root ganglia neurons were maintained with or without the addition of nerve growth factor or the c-Jun N-terminal kinase inhibitor, (D)-JNKII. Few dorsal root ganglia neurons survived nerve growth factor deprivation, whereas neurons supplied with nerve growth factor survived and exhibited extensive axonal outgrowth. Activated c-Jun was present in the nuclei of neurons with regenerating axons, but not in apoptotic neurons. c-Jun N-terminal kinase inhibition reduced the number of p-c-Jun immunoreactive and regenerating neurons, and increased cell death. Thus, activation of c-Jun seems to be required for survival and regeneration of developing sensory neurons.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
1655-1659
Publikation/Tidskrift/Serie
NeuroReport
Volym
16
Issue
15
Dokumenttyp
Artikel i tidskrift
Förlag
Lippincott Williams & Wilkins
Ämne
- Neurosciences
Nyckelord
- nerve growth
- dorsal root ganglia
- development
- c-Jun
- (D)-JNKII
- rat
- factor
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1473-558X