A novel method for downstream characterization of breast cancer circulating tumor cells following CellSearch isolation.
Författare
Summary, in English
Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several other cancer types. The gold standard technology for detecting CTCs in blood against a backdrop of millions of leukocytes is the FDA-approved CellSearch system (Janssen Diagnostics), which relies on EpCAM-based immunomagnetic separation. Secondary characterization of these cells could enable treatment selection based on specific targets in these cells, as well as providing a real time window into the metastatic process and offering unique insights into tumor heterogeneity. The objective of this study was to develop a method for downstream characterization of CTCs following isolation with the CellSearch system.
Avdelning/ar
- Bröstcancer-genetik
- Tumörmikromiljö
- Avdelningen för translationell cancerforskning
- The Liquid Biopsy och Tumörprogression i Bröstcancer
- Bröstcancerkirurgi
- Kirurgi, Lund
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2015
Språk
Engelska
Publikation/Tidskrift/Serie
Journal of Translational Medicine
Volym
13
Issue
1
Fulltext
- Available as PDF - 21 MB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
BioMed Central (BMC)
Ämne
- Cancer and Oncology
Status
Published
Projekt
- CTC-MBC, Circulating Tumor Cells in Metastatic Breast Cancer
- Breast Cancer Surgery
Forskningsgrupp
- The Liquid Biopsy and Tumor Progression in Breast Cancer
- Breast Cancer Surgery
ISBN/ISSN/Övrigt
- ISSN: 1479-5876