Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor

Summary, in English

The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1.

• Författare: Helen Jongsma; Lina Pettersson; Martina Kvist Reimer; Martin Kanje; Alexandra Waldenström Ellervik; Frank Sundler; Nils Danielsen
• Avdelning/ar: Neural Interfaces; Neurofysiologi; Medicinska fakulteten; Funktionell zoologi; Institutionen för experimentell medicinsk vetenskap
• Publiceringsår: 2001
• Språk: Engelska
• Sidor: 2215-2219
• Publikation/Tidskrift/Serie: NeuroReport
• Volym: 12
• Issue: 10
• Dokumenttyp: Artikel i tidskrift
• Förlag: Lippincott Williams & Wilkins
• Ämne: Neurosciences
• Nyckelord: Dorsal root ganglion; Formalin test; Inflammation; Mechanical von Frey; Neuropeptides; PACAP; Pain measurements; Sciatic nerve injury; Sensory thresholds; Thermal laser
• Status: Published
• Forskningsgrupp: Neural Interfaces; Neurophysiology
• ISBN/ISSN/Övrigt: ISSN: 1473-558X