Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.
Författare
Summary, in English
The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during haematopoietic differentiation.
Publiceringsår
2007
Språk
Engelska
Sidor
995-1001
Publikation/Tidskrift/Serie
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volym
31
Issue
7
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cancer and Oncology
Nyckelord
- IFN
- differentiation
- p53
- haematopoiesis
- TRIM22
- Staf50
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1873-5835