Genetic heterogeneity of hepatitis B and D viruses in chronic infection
Författare
Summary, in English
cDNA sequencing and phylogenetic analysis showed that at least two independent HDV genotype IA strains had been involved in the introduction of hepatitis D virus among the drug addicts of southern Sweden in the early 1970s. The annual HDV RNA evolution rate was determined to be 1.2x10-3 substitutions/nucleotide, which is of the same magnitude as the rates found for other RNA viruses.
Phylogenetic analysis of HDV strains from different parts of the world confirmed the usefulness of the genotype classification. Within genotype I two subgroups, A and B, have previously been described. We observed the occurrence of the HDV genotype I subgroups to manifest geographical restrictions, genotype IA being identified as a western branch found in HDV isolates from USA and West and South Europe, and genotype IB an eastern branch occurring in HDV strains from East European countries and from China, Taiwan and Oceanea. Moreover, we identified a new type I subgroup, tentatively designated IC, occurring as the sole subgroup in several patients from Ethiopia and in a single HDV isolate from Somalia. The Somalian strain and one of the Ethiopian HDV strains were fully sequenced. One HDV isolate from Jordan and one previously described from Lebanon were also found to belong to the IC subgroup.
Publiceringsår
1996
Språk
Engelska
Dokumenttyp
Doktorsavhandling
Förlag
Yong Yuan Zhang, Dept. of Medical Microbiology, Section of Virology, University Hospital, MAS, 205 02 Malmo, SWEDEN,
Ämne
- Microbiology in the medical area
Nyckelord
- bacteriology
- Microbiology
- phylogenetic analysis
- mutant
- mutation
- genetic heterogeneity
- HBV
- HDV
- hepatitis B
- virology
- mycology
- Mikrobiologi
- bakteriologi
- virologi
- mykologi
Status
Published
Handledare
- [unknown] [unknown]
ISBN/ISSN/Övrigt
- ISBN: 91-628-2210-1
- ISRN LUMEDW7MEKB--1017--SE
Försvarsdatum
18 december 1996
Försvarstid
09:15
Försvarsplats
Lecture Hall of Pathology, University Hospital, MAS
Opponent
- Anders Sönnerborg (Doc)