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99mTC-HMPAO-SPECT related to clinical findings in patients with subjective experience of memory deficit

Publiceringsår: 2004
Språk: Engelska
Publikation/Tidskrift/Serie: Proceedings of the 8th Nordic Meeting in Neuropsychology
Dokumenttyp: Konferensbidrag


Objective. The aim was to evaluate cognitive impairments, psychiatric symptoms and cerebral blood flow (CBF) patterns in middle-aged and younger old patients with subjective experience of memory deficits.

Methods. The CBF was measured by 99m-Tc-HMPAO-SPECT. The study group was heterogeneous with patients fulfilling criteria for dementia (n=13) and patients with mild cognitive impairment (MCI; n= 24) as well as with not verified cognitive impairment (Non-MCI; n=17). The MCI patients were subdivided into two groups. The MCI type 1 group (n=14) had isolated memory impairments while the MCI type 2 group (n=10) had memory impairments together with slight verbal and/or visuospatial disturbances.

Results. The MCI type 1 group showed lower blood flow in the left middle/inferior gyrus and in parts of the left inferior parietal lobe compared to the Non-MCI group. The MCI type 2 group showed reductions in the left anterior medial temporal lobe as well as in parts of the posterior cingulate gyrus. The Non-MCI patients reported high incidence (70%) of long-lasting psychosocial stress.

Conclusions. The combination of clinical and CBF data provides diagnostically meaningful information about regional brain dysfunction in patients with memory deficits.


  • Psychiatry
  • Geriatrics


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