Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women
Författare
Summary, in English
OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.
DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by radio immunoassay.
RESULTS: In a multivariate model including birth weight, current weight and age, IGF-1 was significantly inversely associated with birth weight in both cycle phases, while current weight was positively associated with IGF-1 in both cycle phases although only significantly so in the follicular phase. IGF-1 concentrations in both cycle phases showed a non-significant decrease with age.
CONCLUSION: In this group of 19-25-year-old healthy nulliparous women IGF-1 displayed a significant inverse association with birth weight in both cycle phases given that the current weight was adjusted for, while current weight was positively related to IGF-1 concentrations.
Publiceringsår
1998-07
Språk
Engelska
Sidor
8-11
Publikation/Tidskrift/Serie
International Journal of Gynecology & Obstetrics
Volym
62
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Cancer and Oncology
Nyckelord
- Adult
- Birth Weight
- Body Weight
- Female
- Follicular Phase
- Humans
- Insulin-Like Growth Factor I
- Luteal Phase
- Multivariate Analysis
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1879-3479