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From the bone marrow to the thymus: the road map of early stages of T-cell development.

In English

Författare

Summary, in English

The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus.

Publiceringsår

2009

Språk

Engelska

Sidor

487-530

Publikation/Tidskrift/Serie

Critical Reviews in Immunology

Volym

29

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Begell House

Ämne

  • Cell and Molecular Biology

Nyckelord

  • T-Lymphocytes: immunology
  • Thymus Gland: cytology
  • Thymus Gland: immunology
  • Bone Marrow: immunology
  • T-Lymphocytes: cytology

Status

Published

Forskningsgrupp

  • Lymphoid Development and Regulation

ISBN/ISSN/Övrigt

  • ISSN: 1040-8401