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Pericytes limit tumor cell metastasis.

  • Xiaojie Xian
  • Joakim Hakansson
  • Anders Ståhlberg
  • Per Lindblom
  • Christer Betsholtz
  • Holger Gerhardt
  • Henrik Semb
Publiceringsår: 2006
Språk: Engelska
Sidor: 642-651
Publikation/Tidskrift/Serie: Journal of Clinical Investigation
Volym: 116
Nummer: 3
Dokumenttyp: Artikel i tidskrift
Förlag: The Journal of Clinical Investigation


Previously we observed that neural cell adhesion molecule (NCAM) deficiency in P tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient P cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied P cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice. This resulted in beta tumor cell metastases in distant organs and local lymph nodes, demonstrating a role for pericytes in limiting tumor cell metastasis. These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions.


  • Cell and Molecular Biology


  • ISSN: 0021-9738

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