JAK/STAT Signalling in Huntington's Disease Immune Cells.
Författare
Summary, in English
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Both central and peripheral innate immune activation have been described as features of the disease. Isolated human HD monocytes have been shown to produce more cytokines upon LPS stimulation compared to control monocytes. Understanding alterations in the signalling cascades responsible and activated by this increase in pro-inflammatory cytokine production is crucial in understanding the molecular basis of this phenomenon. Here we investigated the signalling cascade most commonly activated by pro-inflammatory cytokines such as IL-6 - the JAK/STAT signalling cascade. Using flow cytometry, we show that one out of three key transcription factors activated by JAK/STAT signalling is altered in primary human HD innate immune cells, suggesting that this pathway may only play a minor, additive role in the immune cell dysfunction in HD.
Avdelning/ar
Publiceringsår
2013-12-13
Språk
Engelska
Publikation/Tidskrift/Serie
PLoS Currents
Volym
5
Fulltext
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Public Library of Science (PLoS)
Ämne
- Neurosciences
Status
Published
Forskningsgrupp
- Biomarkers in Brain Disease
ISBN/ISSN/Övrigt
- ISSN: 2157-3999