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Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

In English

Författare

Summary, in English

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

Publiceringsår

2017-04-18

Språk

Engelska

Sidor

532-548

Publikation/Tidskrift/Serie

Immunity

Volym

46

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Cell Press

Ämne

  • Immunology in the medical area

Status

Published

Forskningsgrupp

  • Mucosal Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1074-7613