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Normative childhood repetitive routines and obsessive compulsive symptomatology in 6-year-old twins

  • Derek Bolton
  • Fruhling Rijsdijk
  • Thalia Eley
  • Thomas O'Connor
  • Jacqueline Briskman
  • Sean Perrin
Publiceringsår: 2009
Språk: Engelska
Sidor: 1139-1146
Publikation/Tidskrift/Serie: Journal of Child Psychology and Psychiatry
Volym: 50
Nummer: 9
Dokumenttyp: Artikel i tidskrift
Förlag: Wiley-Blackwell


Background: To investigate the association between normative repetitive routines of childhood and

paediatric obsessive compulsive symptom syndrome (OCSS) and the extent to which it is genetically

mediated. Methods: In a two-phase design a community sample of 4,662 6-year-old twin-pairs were

sampled and 854 pairs were assessed in the second phase for normative repetitive routines using the

Childhood Routines Inventory (CRI) and for OCSS by maternal-informant diagnostic interview. The

OCSS phenotype was defined using standard diagnostic criteria for obsessive compulsive disorder, though regardless of impairment. Results: In the bivariate model, correlation between the CRI defined phenotype and the OCSS phenotype was estimated to be .40 (95% CI .27–.50), and this correlation was attributable wholly to additive genetic effects. The bivariate model also provided estimates of heritability of the two phenotypes separately: 55% (95% CI 80–89%) for the OCSS phenotype, with the remaining variance attributable mainly to non-shared environment, and 50% (95% CI 39–62%) for CRI assessed normative repetitive routines of childhood, with 36% of the remaining variance attributable to shared environment and 14% to non-shared. Conclusions: The moderate correlation between normative childhood repetitive routines and obsessive compulsive symptomatology, attributable to genetic factors, is consistent with the hypothesis that high levels of this trait in young children constitute a risk factor for the development of obsessive compulsive symptoms.


  • Psychology
  • Obsessive compulsive disorder
  • Childhood Routines Inventory
  • children
  • twins
  • genetics.



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