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BRCA1-positive patients are small for gestational age compared with their unaffected relatives

In English

Författare

Summary, in English

The BRCA1 gene is thought to exert its main function early in life. We, therefore, studied the effects of BRCA1 mutations on birth weight and birth length. This was carried out by comparing 33 women with and without mutations. Birth weight and length were obtained from a self-administered questionnaire. BRCA1 mutations carriers had a significantly lower birth weight (P = 0.0041) compared with non-carriers, after adjustment for gestational age. They were also significantly shorter at birth compared with their unaffected relatives (P = 0.0060), after adjustment for gestational age. The BRCA1 gene thus seems to influence the carriers in utero. The findings could imply that humans heterozygotic for the BRCA1 mutations may be influenced by the mutations during development in utero.

Publiceringsår

1998-02

Språk

Engelska

Sidor

71-368

Publikation/Tidskrift/Serie

European Journal of Cancer

Volym

34

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Cancer and Oncology

Nyckelord

  • Adult
  • BRCA1 Protein
  • Birth Weight
  • Body Height
  • Female
  • Heterozygote
  • Humans
  • Infant, Newborn
  • Infant, Small for Gestational Age
  • Mutation
  • Pedigree

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1879-0852