Prion-like transmission of protein aggregates in neurodegenerative diseases.
Författare
Summary, in English
Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.
Avdelning/ar
Publiceringsår
2010
Språk
Engelska
Sidor
301-307
Publikation/Tidskrift/Serie
Nature Reviews. Molecular Cell Biology
Volym
11
Issue
4
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Neurosciences
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1471-0072