Protein kinase C modulation of the ethanol effect on serotonin2 receptor transduction in astrocytes

Summary, in English

Acute ethanol exposure stimulated serotonin2 receptor signalling in cultured astrocytes. Pretreatment with the protein kinase C inhibitor H7 significantly increased the ethanol-induced potentiation of [3H]-inositol phosphates accumulation. The increase could be explained by an augmented activation of phospholipase C. The results indicate a role of PKC for the modulation of ethanol effects on cellular signalling.

• Författare: Per Simonsson; Elisabeth Hansson; Christer Alling
• Avdelning/ar: Klinisk kemi, Malmö; Avdelningen för klinisk kemi och farmakologi
• Publiceringsår: 1989
• Språk: Engelska
• Sidor: 401-404
• Publikation/Tidskrift/Serie: Alcohol and Alcoholism
• Volym: 24
• Issue: 5
• Länkar: http://alcalc.oxfordjournals.org/cgi/reprint/24/5/401
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford University Press
• Ämne: Substance Abuse
• Status: Published
• Forskningsgrupp: Clinical Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1464-3502