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Addition of cultured Schwann cells to tendon autografts and freeze-thawed muscle grafts improves peripheral nerve regeneration

In English

Författare

  • Y Nishiura
  • Jerker Brandt
  • Anna Nilsson
  • Martin Kanje
  • Lars Dahlin

Summary, in English

The effects of addition of Schwann cells on peripheral nerve regeneration through a novel graft material-the tendon autograft-and a conventional freeze-thawed muscle graft, were studied in the rat sciatic nerve. Adult Schwann cell cultures were established from predegenerated nerves. The Schwann cells were added to the autologous grafts by coculture (tendon autograft) or injection (freeze-thawed muscle graft). Both graft types supported adherence of the added Schwann cells. Addition of cultured Schwann cells to the two different graft models improved regeneration by increasing the rate of axonal outgrowth as compared with similar grafts without added cells.

Publiceringsår

2004

Språk

Engelska

Sidor

157-164

Publikation/Tidskrift/Serie

Tissue Engineering

Volym

10

Issue

1-2

Dokumenttyp

Artikel i tidskrift

Förlag

Mary Ann Liebert, Inc.

Ämne

  • Surgery

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1076-3279