Low serum concentration of all-trans and 13-cis retinoic acids in patients treated with phenytoin, carbamazepine and valproate. Possible relation to teratogenicity
Författare
Summary, in English
All-trans retinoic acid deficiency resulting from ethanol's interference with the synthesis of all-trans retinoic acid from retinol was recently suggested to cause the malformations of the fetal alcohol syndrome. Phenytoin, carbamazepine and valproate, might be teratogenic because they lower the concentration of all-trans retinoic acid in serum, by inducing the enzyme systems in the liver responsible for the metabolism of the all-trans retinoic acid, or by other mechanisms. Here we show, that in patients given therapeutic doses of phenytoin, carbamazepine and valproate, serum all-trans and 13-cis retinoic acid concentrations are indeed significantly lowered. We propose that drugs with this ability should be considered as potential teratogens.
Avdelning/ar
Publiceringsår
1995
Språk
Engelska
Sidor
572-574
Publikation/Tidskrift/Serie
Archives of Toxicology
Volym
69
Issue
8
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Pharmacology and Toxicology
Nyckelord
- Retinoic acid
- Phenytoin
- Carbamazepin
- Valproate
- Teratogenicity
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0340-5761