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Definitive endoderm: a key step in coaxing human embryonic stem cells into transplantable beta-cells.

In English

Författare

  • Henrik Semb

Summary, in English

Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be widely available, it will require an unlimited source of cells to serve as a 'biological' insulin pump. At this time, the development of beta-cells from hESCs (human embryonic stem cells) has emerged as the most attractive alternative. It is envisioned that ultimate success of an in vitro approach to programme hESCs into beta-cells will depend on the ability, at least to a certain degree, to sequentially reproduce the individual steps that characterizes normal beta-cell ontogenesis during fetal pancreatic development, including definitive endoderm from which all gastrointestinal organs, including the pancreas, originate. In the present article, differentiation of hESCs into putative definitive endodermal cell types is reviewed.

Publiceringsår

2008

Språk

Engelska

Sidor

272-275

Publikation/Tidskrift/Serie

Biochemical Society Transactions

Volym

36

Issue

Pt 3

Dokumenttyp

Artikel i tidskrift

Förlag

Biochemical Society

Ämne

  • Biochemistry and Molecular Biology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0300-5127