A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia
Författare
Summary, in English
The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re-evaluation: the leukaemic cells showed signs of differentiation, and active erythrophagocytosis was a particularly conspicuous feature. We suggest that t(8;16) (p11;p13) represents a new consistent abnormality in acute monocytic leukaemia, specifically associated with the differentiated subtype (M5b) and with pronounced phagocytic activity by the leukaemic monocytes.
Avdelning/ar
Publiceringsår
1987
Språk
Engelska
Sidor
323-326
Publikation/Tidskrift/Serie
British Journal of Haematology
Volym
66
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Hematology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0007-1048