Number of spikes in climbing fibers determines the direction of cerebellar learning.
Författare
Summary, in English
Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.
Avdelning/ar
Publiceringsår
2013
Språk
Engelska
Sidor
13436-13440
Publikation/Tidskrift/Serie
Journal of Neuroscience
Volym
33
Issue
33
Fulltext
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Society for Neuroscience
Ämne
- Neurosciences
Status
Published
Projekt
- Thinking in Time: Cognition, Communication and Learning
Forskningsgrupp
- Associative Learning
ISBN/ISSN/Övrigt
- ISSN: 1529-2401